How does spravato work

Dec 14, 2023 · Use for Spravato. Your doctor can help determine if you can Dec 20, 2021 · Intranasal esketamine treatment using Spravato® treats depression by being inhaled through the nose. Ketamine has been used for years as an anesthetic, but it has also shown promise in treating depression. Dec 19, 2023 · Cost and coverage of psychedelic therapy for depression. Love it. - Guidelines have not been updated to include the place in therapy of any ketamine products. Spravato contains the active substance esketamine. Major depressive disorder (MDD) is a common debilitating disorder characterized by a depressed mood with markedly diminished interest or pleasure in activities, functional impairment, poor quality of life (QoL), suicidal ideation and attempts, self-injurious behaviour, and a high relapse rate. Dec 21, 2023 · Spravato (esketamine) is a prescription drug that’s approved to treat certain forms of depression. 973-266-4400. SPRAVATO ® Safety. Spravato nasal spray is used only in a healthcare setting. To prevent loss of medication, do not prime the device before use. Nov 28, 2023 · Spravato is a nasal spray that contains esketamine, a glutamate receptor modulator that interacts with the brain’s receptors. Spravato increases glutamate, the most abundant neurotransmitter in the brain. Spravato (esketamine), the S-enantiomer of racemic ketamine, is a non-selective, non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor. SPRAVATO® is an FDA-approved nasal spray for treatment-resistant depression (TRD) and major depressive disorder (MDD) with acute suicidal ideation or behavior (MDSI). techniic0l0r. I thought I was building up a tolerance. Feb 26, 2024 · Ketamine and Spravato (esketamine) can help manage treatment-resistant depression. They’re both effective medications, but some evidence suggests that ketamine may be slightly more effective than Spravato. Seconding everyone saying the length of effective treatment varies by person. Use of SPRAVATO® does not preclude the need for hospitalization if clinically warranted, even if patients experience improvement after an initial dose of SPRAVATO®. Spravato is a nasal spray that typically works 2 to 4 hours after being administered. Spravato is also used to treat depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. Follow these administration instructions and read the Instructions Blood Pressure Assessment Before and After Treatment. Dec 19, 2023 · Spravato (esketamine) is a brand-name nasal spray that’s prescribed for certain types of depression in adults. GoodRx coupons are not available at HCP offices for these medications, but there might be other ways you SPRAVATO must be administered under the direct supervision of a healthcare provider. Spravato is Oct 25, 2023 · The recommended dosage of SPRAVATO for the treatment of depressive symptoms in adults with MDD with acute suicidal ideation or behavior is 84 mg twice per week for 4 weeks. However, because it is not FDA-approved, insurance does not cover IV ketamine for depression. Dec 19, 2022 · Ketamine, a drug available in intravenous (IV) and nasal spray (esketamine) forms, is being actively studied for TRD treatment. If you prefer to correspond with us via regular mail, or have inquiries regarding vendor opportunities or marketing/product suggestions, please use the following address: SPRAVATO withMe can help navigate access and affordability processes efficiently so you can focus on your patients. This actually makes the brain create new receptors for dopamine and serotonin received. Spravato may cause fetal harm and women of reproductive potential should consider pregnancy planning and prevention; women should not breastfeed while being treated. Click here to review SPRAVATO® indications and patient stories. 1,2 MDD is one of the most prevalent SPRAVATO® does not preclude the need for hospitalization if clinically warranted, even if patients experience improvement after an initial dose of SPRAVATO®. Assess blood pressure prior to dosing with SPRAVATO [see Warnings and Precautions (5. Glutamate is a powerful excitatory neurotransmitter that regulates learning and memory. SPRAVATO ® is an. ketamine infusions? I've read that spravato can help, but not as much as infusions and a lot more gradually, whereas infusions work significantly and faster but are not covered by insurance, meaning they cost several thousand dollars, which I do not have. It belongs to a group of drugs called NMDA receptor blockers and works by changing the activity of certain brain cells. The safety and effectiveness of SPRAVATO® as an anesthetic have not been established. This mechanism of action is thought to contribute to the antidepressant effects of Spravato in individuals with treatment-resistant depression (TRD Spravato, however, works a bit differently. for eligible commercially insured patients. Monitor each patient for at least 2 hours following administration of SPRAVATO® for resolution of sedation and dissociation, and changes in vital Spravato can cause serious side effects including: Sedation and dissociation. Nov 5, 2023 · How does Spravato work? Spravato contains esketamine, a more potent version of ketamine, and works by increasing levels of glutamate in the brain to promote better communication between brain cells. Satisfaction. Maintenance dosage for week 9 and later. com or call 855-382-6022. Jan 1, 2024 · SPRAVATO is a nasal spray used to reduce the broad range of symptoms of depression. Esketamine, the active medication in Spravato, uses nasal spray delivery. Ease of Use. For example, I often get dizzy and feel like I am slowly spinning in my chair. Spravato is a medicine used to treat adults with major depression that is resistant to treatment. As with other drugs, Spravato can cause side effects, such as nausea and increased Aug 7, 2020 · "Spravato is the first approved antidepressant medication that's been able to demonstrate a reduction in symptoms of major depressive disorder within 24 hours after the first dose," says Dr erience symptoms of depression, or TRD SPRAVATO® is an N-methyl-D-aspartate (NMDA) receptor antagonist that is believed to work diferently by acting on a pathway in the brain where glutamate, a brain chemical, works with other brain chemi. May 27, 2024 · Traditional antidepressants, such as SSRIs and SNRIs, work by altering levels of serotonin and norepinephrine in the brain. To help ensure patient safety, SPRAVATO ® is administered under the supervision of a healthcare provider at a treatment center that is certified in the SPRAVATO ® Risk Evaluation and Mitigation Strategy (REMS) Program. SPRAVATO ® REMS Outpatient Healthcare Setting Enrollment. SPRAVATO ® is intended for patient administration under the direct observation of a healthcare provider, due to risks of serious adverse outcomes resulting from sedation and dissociation caused by SPRAVATO administration, and abuse Spravato is for treatment resistant depression. Spravato. Phone Please call: 1-800-JANSSEN. Esketamine enhances the brain’s learning and memory functions and alleviates the symptoms of depression. Each session had slightly different side effects. Keep in mind that Spravato (esketamine) is only FDA-approved for treatment-resistant depression and major depressive disorder with suicidal ideation. receptor antagonist that is believed to work differently by acting on a pathway in the brain that affects. Spravato is supplied as a spray for intranasal administration. The really cool thing that happens is it targets glutamate increasing levels being released into the body. Part of its FDA approval includes a strict treatment protocol, while ketamine has no similar drug safety program. It is a nasal spray that uses esketamine, which is related to the drug ketamine. However, Spravato must be administered by a healthcare provider because of its potential risks. Mar 7, 2019 · How Fast Does It Work? One of the potential benefits of Spravato is how quickly it can work. The approval of this drug by the FDA is considered to be one of the most significant advances in mental health in the Aug 1, 2023 · SPRAVATO withMe is limited to education for patients about SPRAVATO®, its administration, and/or their disease, and is not intended to provide medical advice, replace a treatment plan from the patient's doctor or nurse, or provide case management services. Get more information here: https://futurepsychsolutions. How does Spravato work? Though it is an easy-to-use nasal spray, its treatment protocol requires administration in a physician’s office under supervision. Important Safety Information What are the experiences with spravato v. Effectiveness. It is used in combination with an SSRI or SNRI medicine (other antidepressants) when at least two other treatments have failed. These side effects may go away during treatment as your body adjusts to the medicine. Dosage may be reduced to 56 mg twice per week based on tolerability. Overdose. Today the U. Tell your healthcare provider right away if you feel like you cannot stay awake or if you feel like you are going to pass out. Conventional antidepressants may not be effective for some people. s. Savings Program. This medicine is a clear, colourless solution, provided in a single-use nasal spray device. It is a medication that is used to treat major depressive disorder in adults who are not responding to traditional antidepressant medications. I just finished 4 weeks of Spravato, twice a week. Serious side effects of SPRAVATO ® include feeling sleepy (sedation or loss of consciousness) feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation); breathing problems (respiratory depression and respiratory arrest); abuse and misuse; increased risk of suicidal thoughts and behavior; increased blood pressure; problems with SPRAVATO ® is the only FDA-approved nasal spray for TRD. Insurance-covered esketamine depression treatment is here at last! Depression relief is in sight, at last! May 2, 2024 · Other side effects of Spravato. Call 1-844-4S-WITHME (1-844-479-4846) Enroll your Step 3: Ask your healthcare provider any questions you have about taking SPRAVATO ® and about the SPRAVATO ® REMS. Esketamine is the s-enantiomer Apr 5, 2022 · How Does Spravato Work? Spravato isn’t like other antidepressant treatment s. This action helps to modulate glutamate, a neurotransmitter associated with mood regulation. SPRAVATO® is an FDA-approved nasal spray that contains esketamine, a rapid-acting and powerful antidepressant. s to balance well-being and depression The exact way. After the first four weeks, you and your doctor will discuss and determine if treatment should Oct 30, 2023 · SPRAVATO is for nasal use only. However, when I last met with my tech/person who administers the meds to me, she had said the latest research shows it can be taken for up to 4 years. Spravato; Descriptions. ketamine IV treatment, both medications can be beneficial to you. The spray operates in conjuncture with your other antidepressants and treatment approaches to provide fast relief and work toward the long-term reduction of symptoms. However, it is believed to work by targeting the glutamate system in the brain. Spravato can help if you have treatment-resistant depression. 6)] Mar 15, 2020 · Esketamine (Spravato) is an active isomer of ketamine that acts as an N -methyl-d-aspartate receptor antagonist. Esketamine is the active enantiomer of ketamine 21 hours ago · SPRAVATO ® is taken with an oral antidepressant. They also have different routes of administration. Eligible commercially insured patients who receive their medication directly through a doctor/treatment provider who does not accept the Savings Card then the patient must pay in full for medication and then submit a rebate request form; for additional information contact the program at 844-479-4846. Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10] [12] is the S (+) enantiomer of ketamine. In contrast, SPRAVATO offers faster relief and works through a different mechanism. Use 2 devices (for a 56 mg dose) or 3 devices (for an 84 mg dose), with a 5-minute rest between use of each device. 5. Apr 26, 2022 · How does Spravato work? Print. The effects of Spravato on those living 1 day ago · Ketamine blocks the N-methyl-D-aspartate (NMDA) receptor, which seems to be its depression-reducing kingpin. . Hope that helps. The effectiveness of Spravato in preventing suicide or in reducing suicidal ideation or behavior has not been demonstrated. Spravato is a healthcare provider (HCP) administered medication. HCP administered medications are sold and given to you by your physician. Reply. edication costs$8,150 maximum program benefit pe. Images. Spravato is a prescription medication used to treat depression in adults. Standard antidepressant medications boost levels of naturally formed chemicals in the brain like dopamine, norepinephrine, glutamate, and serotonin. Mechanism of Action. com or call Future Psych Solutions at (803) 335-5232 Mar 7, 2019 · Future of Work by Charter; manufactured by Johnson & Johnson’s Janssen Pharmaceuticals and sold under the brand name Spravato, is intended for adults with treatment-resistant depression Description and Brand Names. VA to make new nasal spray drug available for treatment-resistant depression - VA News. 7)]. Some side effects of esketamine may occur that usually do not need medical attention. It was just as intense when I’d taken care of my runny nose as it had previously been. Ketamine is typically injected into a vein, while Spravato is administered as a nasal Spravato is a medication that was approved by the FDA in March 2019. [5] [13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression. Create an Account. It can remove happiness and lead to self-destruction. SPRAVATO ® is a nasal spray that the FDA approved to treat adults with TRD. This could be at a different location than your usual doctor’s office. As glutamate levels increase, the neurotransmitter starts to “excite” cells in the brain. A comfortable neck pillow, blanket, and cozy pair of socks or slippers. Use of Spravato does not preclude the need for hospitalization if clinically warranted, even if patients experience improvement after an initial dose of Spravato. • 27 days ago. SPRAVATO® works very quickly and has an extremely high success rate Key takeaways. ( 1-800-526-7736) Monday-Friday, 9 AM - 8 PM ET. Esketamine nasal spray, on the other hand, is likely to be a treatment covered by insurance. At most clinics, ketamine-assisted therapy, which includes a dose of ketamine and talk therapy, costs between $350 and $500 per session Treatment centers must comply with full SPRAVATO® REMS requirements. SPRAVATO ® may cause sleepiness (sedation), fainting, dizziness, spinning sensation, anxiety, or feeling disconnected from yourself, your thoughts, feelings, space and time (dissociation). . The doctor’s office will process any payments related to your visit and treatment. SPRAVATO ® spray contains esketamine, a variant of the anesthetic ketamine. If baseline blood pressure is elevated (e. Spravato withMe Savings Program Medical Claims Rebate. ° Tell your healthcare provider right away if you feel like you cannot stay awake or Though esketamine is a substrate of the above CYP-enzyme pathways, it does not appear to be an inhibitor or inducer of said pathways. S. m limits apply. Spravato works by increasing levels of glutamate, which is a neurotransmitter that helps regulate How does the prior authorization process for SPRAVATO® work? When a prior authorization request is received for medication coverage, the insurance plan will determine if the member’s benefit plan includes coverage for it and whether the plan requires covered services to be medically necessary. These effects happened on the day of treatment and have gone away. I stayed at 56mg for most of the treatments because I saw positive results within two treatments, and had a bad dissociative reaction on 84mg. Noresketamine demonstrated weak inhibition of CYP3A4. Spravato is a nasal spray treatment for depression known for its effectiveness. We are NJ's only Spravato Certified Treatment Centers for using esketamine in the treatment of depression. Patients with moderate hepatic impairment may require increased monitoring for adverse drug reactions for a longer period of time as a result of the increased Dec 10, 2023 · The usual dosage of Spravato for this condition is 84 mg twice per week for 4 weeks. Dedicated Case Managers provide you with educational support and resources to help you guide your patients through the access process so your patients can start treatment quickly. Follow these administration instructions and read the Instructions erience symptoms of depression, or TRD SPRAVATO® is an N-methyl-D-aspartate (NMDA) receptor antagonist that is believed to work diferently by acting on a pathway in the brain where glutamate, a brain chemical, works with other brain chemi. By incorporating SPRAVATO® into your practice, you can provide a life-saving treatment option for patients who have not responded to other Jan 22, 2024 · They work differently than most other antidepressants. Esketamine nasal spray is used together with an antidepressant taken by mouth, to treat patients with depression who have previously received at least 2 antidepressant treatments that did not work well (treatment-resistant depression). So, it grows the brain making other medications work better and working as a treatment in itself. n the same day. Learn how Spravato works, its side effects, cost, dosage, and more. Unlike traditional antidepressants, like SSRIs and SNRIs, which can take up to 4 to 6 weeks to notice initial effects, Spravato can start working in as little as a few hours . How does the SPRAVATO® REMS work? 3 Before Prescribing/ Dispensing SPRAVATO® Before Starting SPRAVATO® for each Patient During SPRAVATO® Treatment Supervise patient administration of SPRAVATO®. There are ways to save on Auvelity and Spravato. Aug 23, 2023 · Spravato is a nasal spray that is used together with medication taken by mouth to treat adults with depression that is resistant to to other treatments. If you have any questions, please call us at: 844-4S-WITHME (844-479 I’ve digressed, AGAIN. Nope. SPRAVATO® is not approved as an anesthetic agent. Dosage for weeks 1–4. Our depression doctors are accessible 24/7 to our patients. CareWell Health’s Adult Outpatient Behavioral Health Program now offers an amazing breakthrough in depression treatment: SPRAVATO® is the first FDA-approved nasal spray for adults with hard-to-treat depression and major depressive disorder. Effectiveness in preventing suicide or in reducing suicidal ideation or behavior has not been demonstrated; use of esketamine intranasal does not preclude the need for hospitalization if clinically warranted, even if patients experience improvement after an initial dose; Blood pressure monitoring. Introduction. The SPRAVATO ® Treatment Experience. Outpatient Healthcare Settings must be certified in the SPRAVATO ® REMS in order to prescribe product. 1. , >140 mmHg systolic, >90 mmHg diastolic), consider the risks of short term increases in blood pressure and benefit of SPRAVATO treatment [see Warnings and Precautions (5. Esketamine is one of the two mirror-image molecules that make up its parent molecule, ketamine. This medication may cause drowsiness, dizziness, fainting, anxiety, or serious How long does it take for esketamine to work? Esketamine reaches peak concentrations in the body in between 20 and 40 minutes. It is a nasal spray form of esketamine, which is a derivative of ketamine. Blood Pressure Assessment Before and After Treatment Assess blood pressure prior to dosing with SPRAVATO [see Warnings and Precautions (5. The ketamine-induced activity in the brain leads to the reduction of severe bipolar depression symptoms. Department of Veterans Affairs (VA) announced its health care providers will now be able to offer the newly approved Spravato nasal spray for treatment-resistant depression. Reviews (31) Warnings: Esketamine is given in a doctor's office or medical clinic. When these sensations become too intense, the overall experience can become quite stressful. Your healthcare team will watch you closely for at least 2 hours after you receive Jun 5, 2024 · SPRAVATO is intended for administration by the patient under the direct supervision of a healthcare professional, using 2 devices (for a 56 mg dose) or 3 devices (for an 84 mg dose), with a 5-minute rest between use of each device to allow medication to be absorbed. More serious side effects include high blood pressure, slowed breathing, and misuse. Dec 19, 2023 · What Is Spravato and How Does Spravato Work? Spravato, or Esketamine, is a prescription nasal spray approved by the FDA for use along with an oral antidepressant for adults with treatment-resistant depression (TRD) and major depressive disorder (MDD). 1, 2 The exact antidepressant mechanism is unknown, but it is labeled as adjunctive May 14, 2024 · A knitting or crocheting project. Anyway-Take good care of your nose and the medicine will work much better. Treatment center protocols should be followed for handling Schedule III products in accordance with federal, state, and local regulations. 7)] . The exact way SPRAVATO ® works is not fully understood. The medication may make you more sensitive to rough or tight fabrics, so this can help you feel more relaxed. These neurotransmitters are the chemical messengers of the brain, key to initiating and regulating how cells communicate. The drug is administered through a nasal spray SPRAVATO may cause sleepiness (sedation), fainting, dizziness, spinning sensation, anxiety, or feeling disconnected from yourself, your thoughts, feelings, space and time (dissociation), and breathing problems (respiratory depression and respiratory arrest). Glutamate also encourages the brain to learn, memorize Spravato is a nasal spray solution. Award. Esketamine. g. Assess blood pressure before administration Overall rating 4. The nasal spray device delivers a total of 28 mg of esketamine. For SPRAVATO ® REMS Program information contact: Phone: 1-855-382-6022 Fax: 1-877-778-0091 Mar 6, 2019 · How Does Spravato Work? Part of the reason that Spravato is making a splash is its primary ingredient. Treatment may include up to three devices administered. As a result, I feel nauseous. If you have any bothersome side effects, your doctor may lower your dosage to 56 mg twice per week. Dec 17, 2023 · Spravato (esketamine) has been shown to work well for treatment-resistant depression in people who have both depression and anxiety. Runny nose was all. glutamate. This medicine may make you feel sleepy or dizzy, pass out, or cause anxiety. For full REMS requirements, visit SPRAVATOrems. This medicine can help improve the symptoms of your disease and reduce the chance of your symptoms coming back. SPRAVATO™, also known as esketamine, is a nasal spray that rapidly alleviates depressive symptoms and when used in conjunction with therapy, assists in rapid healing of treatment-resistant depression and other mood disorders. It hasn't been studied for the treatment of anxiety. • SPRAVATO® is not approved as an anesthetic agent. Maintenance dosage for weeks 5–8. Jun 5, 2024 · Rothärmel et al (2022)4 conducted an open-label, single-arm, retrospective pilot study that evaluated the efficacy and safety of SPRAVATO in adult patients with comorbid TRD and chronic PTSD who received treatment between February 2020 and November 2021 (N=11). I’m sure of it. SPRAVATO ® is taken twice a week for the first four weeks. 7. calendar year. SPRAVATO was administered at 56 or 84 mg twice weekly during weeks 1-4, 56 or 84 mg Jun 1, 2024 · Description and Brand Names. Auvelity is an oral tablet that begins working in about 1 week. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. SPRAVATO® (esketamine) CIII nasal spray is the S-enantiomer of racemic ketamine. Spravato may cause sleepiness (sedation), fainting, dizziness, spinning sensation, anxiety, or feeling disconnected from yourself, your thoughts, feelings, space and time (dissociation). Summary of Black Box Warnings SPRAVATO is for nasal use only. Spravato is available in pack sizes containing 1, 2, 3, or 6 nasal spray devices and as multipacks containing 12 (4 packs of 3) or 24 (8 packs of 3) nasal spray devices. Spravato® (esketamine) is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist indicated, in conjunction with an oral antidepressant, for the treatment of treatment-resistant depression (TRD) in adults and depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. Learn how Spravato works, how long it takes to work, and how to access it in this comprehensive guide. Additionally, the effectiveness of Spravato in preventing suicide has not been demonstrated. The effectiveness of SPRAVATO® in preventing suicide or in reducing suicidal ideation or behavior has not been demonstrated. How Does Spravato Work? Traditionally, Spravato works by helping to balance out levels of neurotransmitters like dopamine and serotonin. May 11, 2023 · How does Spravato work? The exact mechanism by which Spravato works is not fully understood. Spravato is not approved as an anesthetic agent. Progr. It targets specific receptors in the brain and may help If you suffer from treatment-resistant depression and anxiety, get in touch with our clinic to schedule an appointment and find out whether Spravato® is an option that can work for you. There is a program benefit limit of list price of the medication and a quantity limit of three devices per day or 23 devices in. It’s also a good idea to wear loose, comfortable clothing to your Spravato treatment sessions. SPRAVATO® is a Schedule III controlled substance. Aug 3, 2020 · · SPRAVATO® is the first and only approved antidepressant medication shown to begin improving depressive symptoms with the first dose in this challenging to treat patient population · Approval is based on Phase 3 data showing SPRAVATO® reduced depressive symptoms in as little as four hours in some patients, with symptom improvement maintained through the four-week treatment period Interactions. It rebalances glutamate and GABA as well as facilitates the development of new receptors and synapses. Nov 19, 2021 · Spravato is a safe medication to take in the care of professionals, however because of its potency, it can easily be misused and cause life-threatening effects. Mail. Most Spravato side effects are mild and short-lived. After 4 weeks of treatment with SPRAVATO, evidence of therapeutic benefit should be evaluated to Feb 2, 2024 · Common Spravato side effects include dissociation (feeling disconnected from your mind or body), drowsiness, and dizziness. It works much more rapidly than traditional antidepressants and is preferred for use in someone experiencing an acute major depressive episode or even thoughts of self harm. Glutamate is the most abundant neurotransmitter in the brain. Dec 19, 2023 · Spravato is a brand-name nasal spray that contains esketamine, a drug that acts on the brain to treat certain types of depression. You administer SPRAVATO ® nasal spray yourself under the supervision of a healthcare provider at a certified SPRAVATO ® treatment center. Read our patient reviews. Scroll down for the recommended dosing/administration for each indication. It is used to treat treatment-resistant depression and acute suicidality in adults. Tell your healthcare provider right away if you feel like you cannot stay awake About SPRAVATO® for Treatment-Resistant Depression (TRD) Proven efficacy with safety evaluated in over 1700 adults with treatment-resistant depression (TRD) across six studies: Five Phase 3 studies and one Phase 2 dose ranging study 1. NMDA. Both ketamine and esketamine are given in a doctor’s office or a clinic, and each is typically used alongside another antidepressant. This medicine may also cause a spinning feeling or an out-of-body feeling (like you are separated from your thoughts, feelings, surroundings, yourself, or time). IV-infused ketamine is an FDA-approved anesthetic for surgical and medical procedures. Oct 3, 2022 · Second, aside from its psychological or psychoactive effects, Spravato causes physical sensations that tend to be more unpleasant. Feb 22, 2024 · Warning. Instead of activating dopamine, serotonin, and norepinephrine, it increases glutamate levels. Oct 18, 2019 · Overview. No referral needed. Severe depression is a chronic condition. SPRAVATO is used in people who have tried other antidepressant medicines but have not benefitted from them. Drug information provided by: Merative, Micromedex® US Brand Name. The nasal spray device delivers a total of 28 mg of SPRAVATO. Glutamate is a neurotransmitter that is involved in the regulation of mood, and research has shown that people with depression often have imbalances in their glutamate levels. A treatment session consists of nasal administration of SPRAVATO and post-administration observation under supervision. treatment-resistant depression (TRD) first dose of 56 mg followed by either Whether you choose SPRAVATO® nasal spray vs. Best of luck to ya. How Does Spravato Work? Unlike traditional antidepressants that target the neurotransmitters serotonin, norepinephrine, and dopamine, Spravato operates on the N-methyl-D-aspartate (NMDA) receptors in the brain. While effective for many, they often take several weeks to show benefits and may not work for people with treatment-resistant depression. kj cl rt em iv un my lz ym pa